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Targeted Allele Detail
Symbol: Nogtm1Amc
Name: noggin; targeted mutation 1, Andrew P McMahon
MGI ID: MGI:1862000
Synonyms: Nog-, Nog9E, noggin-, NogginlacZ
Gene: Nog  Location: Chr11:89300638-89302332 bp, - strand  Genetic Position: Chr11, 54.34 cM
Germline Transmission:  Earliest citation of germline transmission: J:47724
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
Mutation detailsGene targeting generated a null allele by fusing the first 10 amino acids of coding sequence in-frame to the lacZ gene. The remainder of the coding sequence and some of the 3' flanking sequence of the gene were deleted. Ectopic expression of the resulting transcript was noted. (J:47724)
View phenotypes for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 231 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Nog Mutation:  8 strains or lines available
Phenotypic Similarity to Human Syndrome: Holoprosencephaly in mice homozygous for Nogtm1Amc and heterozygous for Smad3tm1Xfw in J:161524

Original:  J:47724 McMahon JA, et al., Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite. Genes Dev. 1998 May 15;12(10):1438-52
All:  48 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.21
The Jackson Laboratory