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Targeted Allele Detail
Symbol: Kif3atm1Gsn
Name: kinesin family member 3A; targeted mutation 1, Lawrence SB Goldstein
MGI ID: MGI:1861960
Synonyms: KIF3A-, Kif3an, Kif3atm1Maz
Gene: Kif3a  Location: Chr11:53458206-53492794 bp, + strand  Genetic Position: Chr11, 31.97 cM, cytoband A5-B1
Kif3atm1Gsn/Kif3atm1Gsn embryos lack cilia on cells in the node

Show the 5 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:54575
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsExon 2 was deleted by cre recombinase removal of a targeting vector containing the exon flanked by loxP sites. The resulting transcript was translated out of reading frame, generating a 62 amino acid nonsense protein. Northern and Western blots of heterozygous mutants showed that no fragments or aberrant products were made from the mutant gene. Western blots of homozygous mutants showed an absence of the targeted protein. This allele was generated from Kif3atm2Gsn. (J:54575)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 24 assay results
In Structures Affected by this Mutation: 20 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Kif3a Mutation:  24 strains or lines available
Original:  J:54575 Marszalek JR, et al., Situs inversus and embryonic ciliary morphogenesis defects in mouse mutants lacking the KIF3A subunit of kinesin-II. Proc Natl Acad Sci U S A. 1999 Apr 27;96(9):5043-8
All:  26 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory