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Kcna1tm1Tem
Targeted Allele Detail
Nomenclature
Symbol: Kcna1tm1Tem
Name: potassium voltage-gated channel, shaker-related subfamily, member 1; targeted mutation 1, Bruce L Tempel
MGI ID: MGI:1861959
Synonyms: Kv1.1-, Kv1.1 null
Gene: Kcna1  Location: Chr6:126640397-126646384 bp, - strand  Genetic Position: Chr6, 61.57 cM, cytoband F1-F3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:47349
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced the entire coding region of the gene. RNA from the deleted gene was undetectable by quantitative RNase protection assays of brain tissue from homozygous null mice. (J:47349)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Kcna1 Mutation:  12 strains or lines available
Notes
Phenotypic Similarity to Human Syndrome: Sudden Unexplained Death in Epilepsy (SUDEP) J:164091.

Phenotypic Similarity to Human Syndrome: Epilepsy, Familial Temporal Lobe J:206598.

References
Original:  J:47349 Smart SL, et al., Deletion of the K(V)1.1 potassium channel causes epilepsy in mice. Neuron. 1998 Apr;20(4):809-19 HUMAN
All:  29 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory