Kcna1^tm1Tem
Targeted Allele Detail

Summary

• Symbol: Kcna1^tm1Tem
• Name: potassium voltage-gated channel, shaker-related subfamily, member 1; targeted mutation 1, Bruce L Tempel
• MGI ID: MGI:1861959
• Synonyms: Kv1.1^-, Kv1.1 null
• Gene: Kcna1 Location: Chr6:126617360-126623347 bp, - strand Genetic Position: Chr6, 61.57 cM, cytoband F1-F3
• Alliance: Kcna1^tm1Tem page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:47349
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced the entire coding region of the gene. RNA from the deleted gene was undetectable by quantitative RNase protection assays of brain tissue from homozygous null mice. (J:47349)

Disease models

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Kcna1 Mutation: 26 strains or lines available

References

• Original: J:47349 Smart SL, et al., Deletion of the K(V)1.1 potassium channel causes epilepsy in mice. Neuron. 1998 Apr;20(4):809-19 HUMAN
• All: 59 reference(s)