Jup^tm1Ruiz
Targeted Allele Detail

Summary

• Symbol: Jup^tm1Ruiz
• Name: junction plakoglobin; targeted mutation 1, Patricia Ruiz
• MGI ID: MGI:1861958
• Synonyms: gamma-cat^-, plakoglobin-
• Gene: Jup Location: Chr11:100259784-100288589 bp, - strand Genetic Position: Chr11, 63.47 cM
• Alliance: Jup^tm1Ruiz page

Blood supply, particularly of liver and placenta, is reduced in Jup^tm1Ruiz/Jup^tm1Ruiz mice at E12

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:64280
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced a large part of exon 3, the following intronic sequences, and the 5' region of exon 4 of the gene, encoding amino acids 70 - 160. Northern and Western blots on E11.5 embryos showed no mRNA and protein, respectively, of the targeted gene. (J:64280)

Disease models

Expression

In Mice Carrying this Mutation:	6 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Jup Mutation: 162 strains or lines available

References

• Original: J:64280 Ruiz P, et al., Targeted mutation of plakoglobin in mice reveals essential functions of desmosomes in the embryonic heart. J Cell Biol. 1996 Oct;135(1):215-25
• All: 10 reference(s)