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Il4ratm1Sz
Targeted Allele Detail
Nomenclature
Symbol: Il4ratm1Sz
Name: interleukin 4 receptor, alpha; targeted mutation 1, Leonard Shultz
MGI ID: MGI:1861951
Synonyms: IL-4R-, IL-4Ralpha-, Il-4ralphatm1Sz, Il4ratm1, IL-4R KO
Gene: Il4ra  Location: Chr7:125552282-125579474 bp, + strand  Genetic Position: Chr7, 68.94 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:43656
Parent Cell Line:  BALB/c-I (ES Cell)
Strain of Origin:  BALB/cJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    A neomycin resistance cassette replaced exons 7 - 9 of the gene. (J:43656)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Il4ra Mutation:  26 strains or lines available
References
Original:  J:43656 Noben-Trauth N, et al., An interleukin 4 (IL-4)-independent pathway for CD4+ T cell IL-4 production is revealed in IL-4 receptor-deficient mice. Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10838-43
All:  127 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/11/2019
MGI 6.14
The Jackson Laboratory