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Il5tm1Kopf
Targeted Allele Detail
Nomenclature
Symbol: Il5tm1Kopf
Name: interleukin 5; targeted mutation 1, Manfred A Kopf
MGI ID: MGI:1861948
Synonyms: IL-5-, IL-5null
Gene: Il5  Location: Chr11:53720794-53725103 bp, + strand  Genetic Position: Chr11, 31.99 cM, cytoband A5/B1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:30867
Parent Cell Line:  BL/6-III (ES Cell)
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
    A neomycin resistance cassette was inserted into exon 3 of the gene. (J:30867)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 5 strains available      Cell Lines: 0 lines available
Carrying any Il5 Mutation:  24 strains or lines available
References
Original:  J:30867 Kopf M, et al., IL-5-deficient mice have a developmental defect in CD5+ B-1 cells and lack eosinophilia but have normal antibody and cytotoxic T cell responses. Immunity. 1996 Jan;4(1):15-24
All:  70 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory