About   Help   FAQ
Targeted Allele Detail
Symbol: Gt(ROSA)26Sortm1Sor
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Philippe Soriano
MGI ID: MGI:1861932
Synonyms: Gt(ROSA)26Sor, Gt(ROSA)26Sortm1(LacZ)Cos, Gtrosa26tm1Sor, Gtrosa26tm/Sor, loxP-Stop-loxP lacZ reporter, LSL-LacZ, R26-Cond-lacZ, R26-floxstop-lacZ, R26fslz, R26LacZ, R26-LNL-LacZ, R26R, R26R-lacZ, R26RLacZ, R26RZ, Rosa26 cre reporter, ROSA26fl, ROSA26-floxed Neo-LacZ, ROSA26-flox-STOP-flox-lacZ, Rosa26LacZ, ROSA26-LacZ, Rosa26-lacZ cre reporter, Rosa26-LacZloxP, ROSA26::LNL::LacZ, ROSA26-loxP, Rosa26loxP-STOP-lacZ, Rosa26-LoxSTOPLox-LacZ, Rosa26r-, ROSA26R, ROSA26Rflox, Rosa26RlacZ, Rosa26R-lacZ, Rosa26RLacZ, ROSA26Sortm1Sor, Rosa26stop-LacZ, ROSA26XneorXlacZ, Rosa2R, RosaLoxP, Rosa-LoxP-Stop-LoxP-LacZ, RS, STOP-lacZ
Gene: Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Germline Transmission:  Earliest citation of germline transmission: J:64292
Parent Cell Line:  AK7 (ES Cell)
Strain of Origin:  129S4/SvJaeSor
Allele Type:    Targeted (Conditional ready, Reporter)
Mutation:    Insertion
Mutation detailsA targeting vector was designed from the original gene trap strain, ROSA beta-geo26, to include a splice acceptor sequence (SA), a neo expression cassette flanked by loxP sites, a lacZ gene, and a polyadenylation (bpA) sequence inserted at a unique Xba1 site approximately 300-bp 5' of the original gene-trap integration site. In addition, a triple polyadenylation sequence was added to the 3' end of the neo expression cassette to prevent transcriptional read-through. Presence of the floxed neo cassette prevents lacZ expression. When crossed with a cre transgenic strain, lacZ is expressed in all cells/tissue where Cre is expressed. (J:64292)
Inheritance:    Not Specified
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 408 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 8 strains available      Cell Lines: 1 line available
Carrying any Gt(ROSA)26Sor Mutation:  758 strains or lines available
Original:  J:64292 Soriano P, Generalized lacZ expression with the ROSA26 Cre reporter strain [letter]. Nat Genet. 1999 Jan;21(1):70-1
All:  2657 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.19
The Jackson Laboratory