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Targeted Allele Detail
Symbol: Gcktm1Efr
Name: glucokinase; targeted mutation 1, Shimon Efrat
MGI ID: MGI:1861929
Synonyms: GK-
Gene: Gck  Location: Chr11:5900820-5950081 bp, - strand  Genetic Position: Chr11, 3.88 cM
Germline Transmission:  Earliest citation of germline transmission: J:28756
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA fragment of the gene spanning exon 2 was replaced by a neomycin resistance cassette, resulting in a deletion and a frame shift of the transcript. Mice heterozygous for the targeted mutation had a 37% reduction in glucose phosphorylation activity in islet homogenates and a 28% reduction of activity in liver compared with wild-type littermates. (J:28756)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gck Mutation:  37 strains or lines available
Original:  J:28756 Bali D, et al., Animal model for maturity-onset diabetes of the young generated by disruption of the mouse glucokinase gene. J Biol Chem. 1995 Sep 15;270(37):21464-7
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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