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Targeted Allele Detail
Symbol: Gabrdtm1Geh
Name: gamma-aminobutyric acid (GABA) A receptor, subunit delta; targeted mutation 1, Gregg E Homanics
MGI ID: MGI:1861926
Synonyms: delta-, delta0
Gene: Gabrd  Location: Chr4:155469436-155482549 bp, - strand  Genetic Position: Chr4, 86.17 cM
Germline Transmission:  Earliest citation of germline transmission: J:64288
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsInsertion of a MC1-neomycin resistance cassette into exon 4 disrupted the gene. Northern blot analysis of cerebellar total RNA from homozygous mutant adult mice detected moderate levels of a novel 2.3kb transcript but not the 1.9kb wild-type transcript. Western blot analysis of cerebellar membranes did not detect the wild-type protein in homozygous mutant mice. (J:64288)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gabrd Mutation:  19 strains or lines available
Original:  J:64288 Mihalek RM, et al., Attenuated sensitivity to neuroactive steroids in gamma-aminobutyrate type A receptor delta subunit knockout mice. Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12905-10
All:  52 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory