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Gabrdtm1Geh
Targeted Allele Detail
Nomenclature
Symbol: Gabrdtm1Geh
Name: gamma-aminobutyric acid (GABA) A receptor, subunit delta; targeted mutation 1, Gregg E Homanics
MGI ID: MGI:1861926
Synonyms: delta-, delta0
Gene: Gabrd  Location: Chr4:155469436-155482549 bp, - strand  Genetic Position: Chr4, 86.17 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:64288
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsInsertion of a MC1-neomycin resistance cassette into exon 4 disrupted the gene. Northern blot analysis of cerebellar total RNA from homozygous mutant adult mice detected moderate levels of a novel 2.3kb transcript but not the 1.9kb wild-type transcript. Western blot analysis of cerebellar membranes did not detect the wild-type protein in homozygous mutant mice. (J:64288)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gabrd Mutation:  19 strains or lines available
References
Original:  J:64288 Mihalek RM, et al., Attenuated sensitivity to neuroactive steroids in gamma-aminobutyrate type A receptor delta subunit knockout mice. Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12905-10
All:  52 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory