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Cux1tm1Ejn
Targeted Allele Detail
Nomenclature
Symbol: Cux1tm1Ejn
Name: cut-like homeobox 1; targeted mutation 1, Ellis J Neufeld
MGI ID: MGI:1861916
Synonyms: deltaCR1
Gene: Cux1  Location: Chr5:136248135-136567490 bp, - strand  Genetic Position: Chr5, 75.96 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:49157
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced a genomic fragment containing exons 10 and 11. Western blot analysis on spleen and thymus extracts of homozygous mice demonstrated that a mutant protein that lacked cut domain 1, but retains DNA binding activity, was produced from this allele. (J:49157)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cux1 Mutation:  16 strains or lines available
References
Original:  J:49157 Tufarelli C, et al., Hair defects and pup loss in mice with targeted deletion of the first cut repeat domain of the Cux/CDP homeoprotein gene. Dev Biol. 1998 Aug 1;200(1):69-81
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/09/2019
MGI 6.13
The Jackson Laboratory