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Targeted Allele Detail
Symbol: Ccr5tm1Kuz
Name: chemokine (C-C motif) receptor 5; targeted mutation 1, William A Kuziel
MGI ID: MGI:1861911
Synonyms: CCR5-, CCR5 KO, Cmkbr5tm1Kuz
Gene: Ccr5  Location: Chr9:123921557-123934153 bp, + strand  Genetic Position: Chr9, 75.05 cM, cytoband F
Ccr5tm1Kuz/Ccr5tm1Kuz and wild-type littermates underwent bile duct ligation or sham operation. Macrophage infiltration was determined by immunohistochemistry for F4/80

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:64293
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe exon containing the entire coding region was replaced with a neomycin resistance gene inserted by homologous recombination. (J:84243)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Ccr5 Mutation:  25 strains or lines available
Original:  J:64293 Huffnagle GB, et al., Cutting edge: Role of C-C chemokine receptor 5 in organ-specific and innate immunity to Cryptococcus neoformans. J Immunol. 1999 Nov 1;163(9):4642-6
All:  167 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory