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Cdkn1ctm1Sje
Targeted Allele Detail
Nomenclature
Symbol: Cdkn1ctm1Sje
Name: cyclin-dependent kinase inhibitor 1C (P57); targeted mutation 1, SJ Elledge
MGI ID: MGI:1861811
Synonyms: Cdkn1c-, p57-, p57KIP2, p57+/-m
Gene: Cdkn1c  Location: Chr7:143458350-143461050 bp, - strand  Genetic Position: Chr7, 88.22 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:40203
Parent Cell Line:  AB2.1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    Replacement of exons 1 and 2 (87% of the Cdkn1c coding region) with a neomycin cassette. (J:40203)
Inheritance:    Recessive
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 25 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cdkn1c Mutation:  7 strains or lines available
References
Original:  J:40203 Zhang P, et al., Altered cell differentiation and proliferation in mice lacking p57KIP2 indicates a role in Beckwith-Wiedemann syndrome. Nature. 1997 May 8;387(6629):151-8
All:  25 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory