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Targeted Allele Detail
Symbol: Cdk5tm1Kul
Name: cyclin-dependent kinase 5; targeted mutation 1, Ashok B Kulkarni
MGI ID: MGI:1861809
Synonyms: Cdk5 (-)
Gene: Cdk5  Location: Chr5:24418241-24423530 bp, - strand  Genetic Position: Chr5, 11.73 cM, cytoband A3-B1
Germline Transmission:  Earliest citation of germline transmission: J:64289
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    Replacement of part of exon III, exons IV and V with a neomycin cassette. (J:64289)
Inheritance:    Recessive
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 24 assay results
In Structures Affected by this Mutation: 11 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Cdk5 Mutation:  6 strains or lines available
Original:  J:64289 Ohshima T, et al., Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death. Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):11173-8
All:  49 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory