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Targeted Allele Detail
Symbol: Cd38tm1Lnd
Name: CD38 antigen; targeted mutation 1, Frances E Lund
MGI ID: MGI:1861803
Synonyms: CD38-, CD38null, Cd38tm1Lud
Gene: Cd38  Location: Chr5:43868553-43912375 bp, + strand  Genetic Position: Chr5, 23.85 cM
Germline Transmission:  Earliest citation of germline transmission: J:49170
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin selection cassette replaced a genomic fragment containing exons 2 and 3, which encode the putative active site of the encoded protein. Homozygous mice lacked transcripts derived from this allele (data not shown). Flow cytometry analysis on splenocytes derived from homozygous mice confirmed that no detectable protein was expressed on the cell surface. (J:49170)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Cd38 Mutation:  27 strains or lines available
Original:  J:49170 Cockayne DA, et al., Mice deficient for the ecto-nicotinamide adenine dinucleotide. Blood. 1998 Aug 15;92(4):1324-33
All:  50 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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