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Pak2Gt(OST104058)Lex
Gene trapped Allele Detail
Nomenclature
Symbol: Pak2Gt(OST104058)Lex
Name: p21 (RAC1) activated kinase 2; gene trap OST104058, Lexicon Genetics
MGI ID: MGI:1861800
Gene: Pak2  Location: Chr16:31835108-31898160 bp, - strand  Genetic Position: Chr16, 22.4 cM
Mutation
origin
Mutant Cell Line:  OST104058
Germline Transmission:  Earliest citation of germline transmission: J:46940
Parent Cell Line:  Lex-1 (ES Cell)
Strain of Origin:  129S5/SvEvBrd
Project Collection: Lexicon
Mutation
description
Allele Type:    Gene trapped (Null/knockout)
Mutation:    Insertion of gene trap vector
 
Mutation detailsThe gene trap cassette consisting of an long terminal repeat (LTR), splice acceptor sequence (SA), internal ribosome entry site-galactosidase/neomycin phosphotransferase fusion gene (IRES-geo), polyadenylation sequence, phosphoglycerate kinase-1 promoter (PGK), puromycin N-acetyltransferase gene, splice donor sequence (SD), and LTR, inserted before exon 2. Western blot analysis indicates that levels of protein in the hippocampus and cortex are reduced in heterozygotes. (J:271067)
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
Genome Browser view of this mutation
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pak2 Mutation:  59 strains or lines available
References
Original:  J:46940 Zambrowicz BP, et al., Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells. Nature. 1998 Apr 9;392(6676):608-11
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory