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Gene trapped Allele Detail
Symbol: Pak2Gt(OST104058)Lex
Name: p21 (RAC1) activated kinase 2; gene trap OST104058, Lexicon Genetics
MGI ID: MGI:1861800
Gene: Pak2  Location: Chr16:31835108-31898160 bp, - strand  Genetic Position: Chr16, 22.4 cM
Mutant Cell Line:  OST104058
Germline Transmission:  Earliest citation of germline transmission: J:46940
Parent Cell Line:  Lex-1 (ES Cell)
Strain of Origin:  129S5/SvEvBrd
Project Collection: Lexicon
Allele Type:    Gene trapped (Null/knockout)
Mutation:    Insertion of gene trap vector
Mutation detailsThe gene trap cassette consisting of an long terminal repeat (LTR), splice acceptor sequence (SA), internal ribosome entry site-galactosidase/neomycin phosphotransferase fusion gene (IRES-geo), polyadenylation sequence, phosphoglycerate kinase-1 promoter (PGK), puromycin N-acetyltransferase gene, splice donor sequence (SD), and LTR, inserted before exon 2. Western blot analysis indicates that levels of protein in the hippocampus and cortex are reduced in heterozygotes. (J:271067)
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
Genome Browser view of this mutation
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pak2 Mutation:  59 strains or lines available
Original:  J:46940 Zambrowicz BP, et al., Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells. Nature. 1998 Apr 9;392(6676):608-11
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory