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Targeted Allele Detail
Symbol: Bcl3tm1Ver
Name: B cell leukemia/lymphoma 3; targeted mutation 1, Inder M Verma
MGI ID: MGI:1861796
Synonyms: Bcl3(-), Bcl3tm1
Gene: Bcl3  Location: Chr7:19808462-19822770 bp, - strand  Genetic Position: Chr7, 9.95 cM
Germline Transmission:  Earliest citation of germline transmission: J:38092
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA ~10 kb genomic fragment containing exons 1-6 was replaced with a hygromycin selection cassette inserted in reverse transcriptional orientation. These sequences encode five ankyrin repeats of the protein. Western blot analysis on spleen lysates derived from homozygous mice confirmed that no detectable protein was produced from this allele. (J:38092)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bcl3 Mutation:  42 strains or lines available
Original:  J:38092 Schwarz EM, et al., Immunological defects in mice with a targeted disruption in Bcl-3. Genes Dev. 1997 Jan 15;11(2):187-97
All:  10 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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