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Targeted Allele Detail
Symbol: Glatm1Kul
Name: galactosidase, alpha; targeted mutation 1, Ashok B Kulkarni
MGI ID: MGI:1861794
Synonyms: alpha-galA-, alpha-Gal A -/0, Gla-
Gene: Gla  Location: ChrX:134588149-134601125 bp, - strand  Genetic Position: ChrX, 56.2 cM, cytoband E-F1
Lipid inclusions with electron-dense concentric lamellar structures in the lysosomes of Glatm1Kul/Y renal tubular cells

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:39394
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 1kb genomic fragment containing part of exon 3 and intron 3 was replaced by a neomycin resistance cassette. (J:39394)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Gla Mutation:  11 strains or lines available
Original:  J:39394 Ohshima T, et al., alpha-Galactosidase A deficient mice: a model of Fabry disease. Proc Natl Acad Sci U S A. 1997 Mar 18;94(6):2540-4
All:  44 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.11
The Jackson Laboratory