Acvr2a^tm1Zuk
Targeted Allele Detail

Summary

• Symbol: Acvr2a^tm1Zuk
• Name: activin receptor IIA; targeted mutation 1, Martin M Matzuk
• MGI ID: MGI:1861779
• Synonyms: actRcII^m1, Acvr2^-
• Gene: Acvr2a Location: Chr2:48704121-48793276 bp, + strand Genetic Position: Chr2, 28.38 cM
• Alliance: Acvr2a^tm1Zuk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:23924
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-hprt minigene replaced a genomic fragment containing the initiation codon and the sequences encoding the signal peptide. Northern blot analysis indicated that no transcript was detectable in liver of homozygous mice. (J:23924)

Disease models

Expression

In Structures Affected by this Mutation:

12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Acvr2a Mutation: 38 strains or lines available

References

• Original: J:23924 Matzuk MM, et al., Different phenotypes for mice deficient in either activins or activin receptor type II [see comments]. Nature. 1995 Mar 23;374(6520):356-60
• All: 12 reference(s)