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Targeted Allele Detail
Symbol: Abcd1tm1Kan
Name: ATP-binding cassette, sub-family D (ALD), member 1; targeted mutation 1, Klaus-Armin Nave
MGI ID: MGI:1861771
Synonyms: ald -
Gene: Abcd1  Location: ChrX:73716597-73738534 bp, + strand  Genetic Position: ChrX, 37.39 cM, cytoband B
Germline Transmission:  Earliest citation of germline transmission: J:44812
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA genomic fragment consisting of a large part of exon 1 was deleted and replaced with a neomycin selection cassette. These sequences encode the translation initiation site and the first four transmembrane domains. A mutated transcript is produced from this allele, but lacks the authentic translation start site and contains stop codons in all three reading frames. (J:44812)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 2 assay results
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Abcd1 Mutation:  11 strains or lines available
Original:  J:44812 Forss-Petter S, et al., Targeted inactivation of the X-linked adrenoleukodystrophy gene in mice. J Neurosci Res. 1997 Dec 1;50(5):829-43
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory