Cux1^tm2Ejn
Targeted Allele Detail

Summary

• Symbol: Cux1^tm2Ejn
• Name: cut-like homeobox 1; targeted mutation 2, Ellis J Neufield
• MGI ID: MGI:1861702
• Synonyms: deltaC
• Gene: Cux1 Location: Chr5:136276989-136596344 bp, - strand Genetic Position: Chr5, 75.96 cM
• Alliance: Cux1^tm2Ejn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:74660
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 20 was deleted and a neomycin resistance cassette was inserted into intron 20. This allele expresses a mutant protein with a deletion in the C terminus, including the homeodomain. (J:74660)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cux1 Mutation: 111 strains or lines available

References

• Original: J:74660 Luong MX, et al., Genetic ablation of the CDP/Cux protein C terminus results in hair cycle defects and reduced male fertility. Mol Cell Biol. 2002 Mar;22(5):1424-37
• All: 8 reference(s)