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Fanclgcd
Transgenic Allele Detail
Nomenclature
Symbol: Fanclgcd
Name: Fanconi anemia, complementation group L; germ cell deficient
MGI ID: MGI:1861640
Synonyms: gcd, Phf9gcd
Gene: Fancl  Location: Chr11:26386135-26471876 bp, + strand  Genetic Position: Chr11, 15.85 cM, cytoband A2-A3
Histological sections of adult Fanclgcd/Fanclgcd mouse gonads

Show the 3 phenotype image(s) involving this allele.

Transgene
origin
Strain of Origin:  (CBA/J x C57BL/6J)F2
Transgene
description
Transgene Type:    Transgenic
Mutations:    Insertion, Intergenic deletion
 
Mutation detailsThis mutation was identified as a transgene insertion that also deletes approximately 150 kb of genomic sequence at the insertion site. This deletion removes exons 4-14 of Fancl and also removes exons 2-11 of a neighboring gene Vrk2. The transgene contains a fragment of goat DNA. A transgene expressing Vrk2 that was introduced into homozygous mice failed to rescue the phenotype, suggesting that the deletion of Fancl was solely responsible for the phenotype seen in these mice. (J:80424)
Inheritance:    Recessive
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 1 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fancl Mutation:  7 strains or lines available
References
Original:  J:21254 Pellas TC, et al., Germ-cell deficient (gcd), an insertional mutation manifested as infertility in transgenic mice. Proc Natl Acad Sci U S A. 1991 Oct 1;88(19):8787-91
All:  5 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/25/2015
MGI 5.21
The Jackson Laboratory