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Transgenic Allele Detail
Symbol: Fanclgcd
Name: Fanconi anemia, complementation group L; germ cell deficient
MGI ID: MGI:1861640
Synonyms: gcd, Phf9gcd
Gene: Fancl  Location: Chr11:26387084-26471883 bp, + strand  Genetic Position: Chr11, 15.85 cM, cytoband A2-A3
Histological sections of adult Fanclgcd/Fanclgcd mouse gonads

Show the 3 phenotype image(s) involving this allele.

Strain of Origin:  (CBA/J x C57BL/6J)F2
Transgene Type:    Transgenic
Mutations:    Insertion, Intergenic deletion
Mutation detailsThis mutation was identified as a transgene insertion that also deletes approximately 150 kb of genomic sequence at the insertion site. This deletion removes exons 4-14 of Fancl and also removes exons 2-11 of a neighboring gene Vrk2. The transgene contains a fragment of goat DNA. A transgene expressing Vrk2 that was introduced into homozygous mice failed to rescue the phenotype, suggesting that the deletion of Fancl was solely responsible for the phenotype seen in these mice. (J:80424)
Inheritance:    Recessive
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 1 assay results
In Structures Affected by this Mutation: 15 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fancl Mutation:  5 strains or lines available
Original:  J:21254 Pellas TC, et al., Germ-cell deficient (gcd), an insertional mutation manifested as infertility in transgenic mice. Proc Natl Acad Sci U S A. 1991 Oct 1;88(19):8787-91
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory