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Chemically induced Allele Detail
Symbol: CrygsOpj
Name: crystallin, gamma S; opacity due to poor secondary fiber cell junctions
MGI ID: MGI:1861635
Synonyms: ENU-410
Gene: Crygs  Location: Chr16:22805203-22811410 bp, - strand  Genetic Position: Chr16, 13.66 cM
Progressive cataract development in CrygsOpj/Crygs+ and CrygsOpj/CrygsOpj mice

Show the 3 phenotype image(s) involving this allele.

Strain of Origin:  (101 x C3H)F1
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
Mutation detailsA single base pair mutation (T to C) in exon 2 replaces Phe with Ser at amino acid position 9 of the protein. The mutant protein shows a concentration dependent decrease in solubility and a loss of secondary structure at near-physiological temperatures. (J:68109)
Inheritance:    Semidominant
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Crygs Mutation:  30 strains or lines available
Original:  J:21950 Favor J, A comparison of the dominant cataract and recessive specific-locus mutation rates induced by treatment of male mice with ethylnitrosourea. Mutat Res. 1983 Aug;110(2):367-82
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.03
The Jackson Laboratory