Arp^BALB/c
QTL Variant Detail

Summary

• QTL variant: Arp^BALB/c
• Name: Arp lymphoid/erythroid hyperplasia; BALB/c
• MGI ID: MGI:1861621
• QTL: Arp Location: Chr5:45650716-45670033 bp Genetic Position: Chr5, Syntenic

Variant origin

• Strain of Specimen: BALB/c

Variant description

• Allele Type: QTL
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Notes

Gross hyperplasia of the thymus, spleen, Peyer's patches, and lymph nodes, along with lymphocytic and metamyelocytic accumulations in the liver and hyperplasia of the bone marrow are caused by a mutation of the Arp gene. Aspects of the pathological picture are consistent with the disorder being due to a primary hemolytic process or autoimmune disorder with secondary hyperplasia (J:6549).

The recessive mutant allele responsible for the disorder appeared in a substrain of BALB/c (J:7273). Occurrence of the disorder also requires presence of a dominant allele of the lyimphoid cytostasis suppressor gene Lus, present in the B10.D2 strain. Lus and Arp assort independently (J:6549).

The gene codes for a surface antigen in lymphocytes; mice of the two homozygous genotypes on the BALB/c background show a range of alloimmune reactions including mixed lymphocyte reaction, host-vs.-graft and graft-vs.-host reactions, and development of weak cytotoxic but strong cytostatic effector lymphocytes which are allo- as well as autoreactive (J:7273).

Mapping and Phenotype information for this QTL, its variants and associated markers

J:7273

Genetic screening of (B10.D2-H2^d x BALB/c)F1 x BALB/c backcross animals revealed linkage between Arp (Arp lymphoid/erythroid hyperplasia) and Lap3 (formerly Pep7) at 67 cM on mouse Chromosome 5. The BALB/c allele of Arp is associated with induction of lymphoproliferative disease. Arp^BALB/c is also associated a Lap3 protein polymorphism exhibiting faster mobility compared to the C57BL/10 variant. Arp interacts with a separate locus named Lus (lymphoid cytostasis suppressor) for development of lymphoproliferative disease.

References

• Original: J:6549 de Giorgi L, et al., Two genes interact to control development of a lymphoid/erythroid hyperplastic disorder of mice. Nature. 1981 Aug 6;292(5823):545-7
• All: 2 reference(s)