Ds
Spontaneous Allele Detail

Summary

• Symbol: Ds
• Name: disorganization
• MGI ID: MGI:1861455
• Gene: Ds Location: unknown Genetic Position: Chr14, Syntenic
• Alliance: Ds page

Ds/+

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: DA/Hu

Mutation description

• Allele Type: Spontaneous
• Mutation: Undefined
• Mutation details: This spontaneous mutation has been mapped to an interval between D14Mit37 and D14Mit88, where an ETn retrotransposon was identified, inserted into intergenic sequence without disruption, between Gata4 and Blk, and is a candidate for causation. (J:1477, J:334481)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ds Mutation: 1 strain or line available

Notes

The Ds mutation arose spontaneously in the inbred DA/Hu strain at The Jackson Laboratory. Ds disrupts the orderly processes of development. Most homozygotes probably die in utero after implantation and before term (J:13012), but some may possibly be normal and viable (J:15709). Heterozygotes may be normal, may deviate slightly, or may be monstrous individuals with multiple defects (J:13012, J:2436).

References

• Original: J:145146 Hummel KP, Disorganization (Ds). Mouse News Lett. 1955;12:29
• All: 14 reference(s)