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Zeb1Tw
Spontaneous Allele Detail
Nomenclature
Symbol: Zeb1Tw
Name: zinc finger E-box binding homeobox 1; twirler
MGI ID: MGI:1861230
Gene: Zeb1  Location: Chr18:5591860-5775467 bp, + strand  Genetic Position: Chr18, 4.42 cM
Inner ear morphology, hearing thresholds, and otoconia of Zeb1Tw/Zeb1+ and Zeb1Tw/Zeb1Tw mice

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Strain of Origin:  STOCK PCS
Mutation
description
Allele Type:    Spontaneous
Mutation:    Single point mutation
 
Mutation detailsA single nucleotide G to A substitution is located 181 bp downstream of Zeb1 exon 1 and 12 bp downstream of exon 1 of the predicted gene Gm10125. This mutation does not affect the adjacent splicing site but does disrupt a predicted Myb binding site. An electrophoretic mobility shift assay demonstrated that a probe carrying this mutation does not interfere with Myb binding, unlike a probe with the wild-type sequence. RT-PCR analysis showed that expression of transcripts containing exons 1a and 2 and exons 2 and 3 were increased compared to wild-type controls. (J:177274)
Inheritance:    Semidominant
Linkage mapping and identification of the Zeb1Tw mutation
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 35 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Zeb1 Mutation:  15 strains or lines available
References
Original:  J:274 LYON MF, Twirler: a mutant affecting the inner ear of the house mouse. J Embryol Exp Morphol. 1958 Mar;6(1):105-16
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/21/2020
MGI 6.14
The Jackson Laboratory