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SfnEr
Radiation induced Allele Detail
Nomenclature
Symbol: SfnEr
Name: stratifin; repeated epilation
MGI ID: MGI:1861121
Synonyms: Er
Gene: Sfn  Location: Chr4:133600556-133602168 bp, - strand  Genetic Position: Chr4, 66.25 cM, cytoband D3
Repeated hair loss in SfnEr/Sfn+ mice

Show the 12 phenotype image(s) involving this allele.

Mutation
origin
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Radiation induced
Mutation:    Insertion
 
Mutation detailsA single T insertion at base pair 622 causes a frame shift mutation at amino acid residue 207 truncating the C-terminus of the protein. This eliminates residues required for ligand interaction. Production of truncated protein was demonstrated immunologically. The hair-loss phenotype could be rescued using a Sfn containing transgene. (J:101891)
Inheritance:    Semidominant
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 17 assay results
In Structures Affected by this Mutation: 46 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sfn Mutation:  11 strains or lines available
Notes
Sfn is on Chr 4 close to pupoid fetus (pf), a mutant which SfnEr closely resembles.
References
Original:  J:29020 Hunsicker, Repeated epilation, Er. Mouse News Lett. 1960;23:58-9
All:  26 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/23/2020
MGI 6.15
The Jackson Laboratory