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Targeted Allele Detail
Symbol: Tfamtm1Lrsn
Name: transcription factor A, mitochondrial; targeted mutation 1, Nils-Goran Larsson
MGI ID: MGI:1860962
Synonyms: TfamloxP
Gene: Tfam  Location: Chr10:71225464-71238280 bp, - strand  Genetic Position: Chr10, 36.83 cM, cytoband B5
Skeletal muscle analysis of Tfamtm1Lrsn/Tfamtm1Lrsn Myl1tm1(cre)Sjb/Myl1+ mice

Show the 4 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:46387
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA single loxP site was inserted 5' to exon 6 and a PCK-neomycin selection cassette followed by an additional loxP site was inserted 3' to exon 7. The insertions did not have any effect on the normal expression of the gene (data not shown). (J:46387)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 14 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tfam Mutation:  4 strains or lines available
Original:  J:46387 Larsson NG, et al., Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice [see comments]. Nat Genet. 1998 Mar;18(3):231-6
All:  53 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory