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Targeted Allele Detail
Symbol: Tfamtm1.1Lrsn
Name: transcription factor A, mitochondrial; targeted mutation 1.1, Nils-Goran Larsson
MGI ID: MGI:1860956
Synonyms: Tfam-
Gene: Tfam  Location: Chr10:71225464-71238280 bp, - strand  Genetic Position: Chr10, 36.83 cM, cytoband B5
Tfamtm1.1Lrsn/Tfamtm1.1Lrsn mice display massive apoptosis at E9.5

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:46387
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsThis allele is a derivative of Tfamtm1Lrsn in which the loxP flanked sequences were removed in the germline by Cre mediated recombination. Mice carrying the Tfamtm1Lrsn allele were mated to mice carrying the TgN(ACTB-Cre)2Mrt transgene to produce progeny in which the loxP flanked sequences were deleted. (J:46387)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 24 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tfam Mutation:  7 strains or lines available
Original:  J:46387 Larsson NG, et al., Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice [see comments]. Nat Genet. 1998 Mar;18(3):231-6
All:  5 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory