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Tlr4tm1Aki
Targeted Allele Detail
Nomenclature
Symbol: Tlr4tm1Aki
Name: toll-like receptor 4; targeted mutation 1, Shizuo Akira
MGI ID: MGI:1860885
Synonyms: TLR4-, TLR4 KO, TLR4-KO
Gene: Tlr4  Location: Chr4:66827584-66930284 bp, + strand  Genetic Position: Chr4, 34.66 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:53519
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsGenomic sequences encoding the transmembrane and cytoplasmic domains (amino acids 86-835) were replaced with a neomycin cassette. Northern blot analysis revealed that no mRNA is produced from this allele in splenocytes derived from homozygous mice. (J:53519, J:91950)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 11 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 5 strains available      Cell Lines: 0 lines available
Carrying any Tlr4 Mutation:  53 strains or lines available
References
Original:  J:53519 Hoshino K, et al., Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J Immunol. 1999 Apr 1;162(7):3749-52
All:  549 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/03/2018
MGI 6.12
The Jackson Laboratory