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Tlr4lps-del
Spontaneous Allele Detail
Nomenclature
Symbol: Tlr4lps-del
Name: toll-like receptor 4; defective lipopolysaccharide response, deletion
MGI ID: MGI:1860755
Synonyms: Tlr4-, TLR4-KO, TLR4lps-
Gene: Tlr4  Location: Chr4:66827584-66930284 bp, + strand  Genetic Position: Chr4, 34.66 cM
Mutation
origin
Strain of Origin:  C57BL/10ScN
Mutation
description
Allele Type:    Spontaneous
Mutation:    Intragenic deletion
 
Mutation detailsThis allele has been characterized by lack of mRNA owing to a deletion of the locus. 74723bp of genomic DNA sequence have been removed, apparently encompasing only the Tlr4 gene. (J:51522, J:122203)
Inheritance:    Recessive
Phenotypes
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Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 5 strains available      Cell Lines: 0 lines available
Carrying any Tlr4 Mutation:  25 strains or lines available
Notes
C57BL/10ScN, C57BL/10ScNJ, and C57BL10/ScCr mice carry this allele.

References
Original:  J:6086 Vogel SN, et al., Characterization of a congenitally LPS-resistant, athymic mouse strain. J Immunol. 1979 Feb;122(2):619-22
All:  194 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory