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Adrb3tm1Lowl
Targeted Allele Detail
Nomenclature
Symbol: Adrb3tm1Lowl
Name: adrenergic receptor, beta 3; targeted mutation 1, Bradford B Lowell
MGI ID: MGI:1860610
Synonyms: beta3-AR -
Gene: Adrb3  Location: Chr8:27225776-27230807 bp, - strand  Genetic Position: Chr8, 15.94 cM, cytoband A2-A4
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:30060
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  FVB/N
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 306bp genomic fragment containing the sequences encoding the third through the fifth transmembrane domains was replaced with a neomycin selection cassette. An RNase protection assay demonstrated that the encoded transcript was not detectable in brown adipose tissue of homozygous mice. (J:30060)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Adrb3 Mutation:  26 strains or lines available
Notes
This allele was generated by direct injection of DNA vectors into FVB/N zygotes. (J:30060)
References
Original:  J:30060 Susulic VS, et al., Targeted disruption of the beta 3-adrenergic receptor gene. J Biol Chem. 1995 Dec 8;270(49):29483-92
All:  38 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory