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Thtm1Srt
Targeted Allele Detail
Nomenclature
Symbol: Thtm1Srt
Name: tyrosine hydroxylase; targeted mutation 1, Suzanne Roffler-Tarlov
MGI ID: MGI:1860480
Synonyms: Th-, TH-null
Gene: Th  Location: Chr7:142892752-142931128 bp, - strand  Genetic Position: Chr7, 88.06 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:54692
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin selection cassette was used to replace sequence from exons 6, 7, and 8. The deleted region encompassed 268 nucleotides encoding a portion of the catalytic domain. Low levels of a peptide, slightly smaller than normal, were detected by Western blot analysis of extracts obtained from homozygous mutant fetuses. The mutant peptide could not be detected by immunohistochemical analysis of fetal adrenals or in fetal or postnatal brains. (J:54692)
Inheritance:    Recessive
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Th Mutation:  23 strains or lines available
References
Original:  J:54692 Rios M, et al., Catecholamine synthesis is mediated by tyrosinase in the absence of tyrosine hydroxylase. J Neurosci. 1999 May 1;19(9):3519-26
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/20/2015
MGI 5.21
The Jackson Laboratory