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Targeted Allele Detail
Symbol: Thratm1Ven
Name: thyroid hormone receptor alpha; targeted mutation 1, Bjorn Vennstrom
MGI ID: MGI:1860441
Synonyms: TRalpha1 -, TRalpha1 KO
Gene: Thra  Location: Chr11:98740638-98769006 bp, + strand  Genetic Position: Chr11, 62.58 cM, cytoband D-E
Germline Transmission:  Earliest citation of germline transmission: J:45675
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA gene targeting construct was designed to disrupt the alpha1 isoform, while maintaining the integrity of the alpha2 isoform, as well as the of the orphan hormone receptor rev-erbAalpha that is transcribed on the opposite strand. RT-PCR was used to confirm these results. (J:45675)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Thra Mutation:  23 strains or lines available
Original:  J:45675 Wikstrom L, et al., Abnormal heart rate and body temperature in mice lacking thyroid hormone receptor alpha 1. EMBO J. 1998 Jan 15;17(2):455-61
All:  43 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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