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Tnftm1Ljo
Targeted Allele Detail
Nomenclature
Symbol: Tnftm1Ljo
Name: tumor necrosis factor; targeted mutation 1, Lloyd J Old
MGI ID: MGI:1860250
Synonyms: TNF-, TNFalpha ko
Gene: Tnf  Location: Chr17:35199381-35202007 bp, - strand  Genetic Position: Chr17, 18.59 cM
HIstology of liver and spleen from C. parvum-treated wild type and Tnftm1Ljo/Tnftm1Ljo mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:41992
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA phosphoglycerate kinase-neomycin cassette replaced nucleotides 3704-5364; this is a deletion of 2.2 kb containing the promoter region, transcription start site, and exons 1 and 2 of the gene. Lack of the protein was demonstrated functionally. (J:41992)
Inheritance:    Semidominant
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 107 assay results
In Structures Affected by this Mutation: 11 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Tnf Mutation:  34 strains or lines available
References
Original:  J:41992 Marino MW, et al., Characterization of tumor necrosis factor-deficient mice. Proc Natl Acad Sci U S A. 1997 Jul 22;94(15):8093-8
All:  95 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory