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Targeted Allele Detail
Symbol: Tnfsf11tm1Pngr
Name: tumor necrosis factor (ligand) superfamily, member 11; targeted mutation 1, Josef M Penninger
MGI ID: MGI:1859962
Synonyms: opgl-, RANKL KO, Tnfsf11-, Trance-
Gene: Tnfsf11  Location: Chr14:78277446-78308043 bp, - strand  Genetic Position: Chr14, 41.26 cM
Germline Transmission:  Earliest citation of germline transmission: J:52369
Parent Cell Line:  E14K (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neomycin cassette disrupted the exon encoding a portion of the TNF-homology domain (amino acids 136-177). Northern blot analysis revealed an absence of message in homozygous mutant animals. (J:52369)
Inheritance:    Recessive
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tnfsf11 Mutation:  21 strains or lines available
Original:  J:52369 Kong YY, et al., OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature. 1999 Jan 28;397(6717):315-23
All:  22 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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