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Targeted Allele Detail
Symbol: Slc30a3tm1Rpa
Name: solute carrier family 30 (zinc transporter), member 3; targeted mutation 1, Richard D Palmiter
MGI ID: MGI:1859820
Synonyms: Znt3-, ZnT3
Gene: Slc30a3  Location: Chr5:31086106-31108237 bp, - strand  Genetic Position: Chr5, 16.97 cM
Germline Transmission:  Earliest citation of germline transmission: J:53059
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 1 through 4 were replaced with a cassette containing nuclear lacZ and neo. Encoded protein was undetectable in brain homogenates from homozygous mutant mice via Western blot analysis. Beta-galactosidase expression was used to observe the activity of the endogenous promoter. (J:53059)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Slc30a3 Mutation:  1 strain or line available
Original:  J:53059 Cole TB, et al., Elimination of zinc from synaptic vesicles in the intact mouse brain by disruption of the ZnT3 gene. Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1716-21
All:  42 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory