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Adrb2tm1Bkk
Targeted Allele Detail
Nomenclature
Symbol: Adrb2tm1Bkk
Name: adrenergic receptor, beta 2; targeted mutation 1, Brian K Kobilka
MGI ID: MGI:1859675
Synonyms: Adrb2-, beta2AR-, Beta2-AR, Beta2-KO
Gene: Adrb2  Location: Chr18:62177817-62179959 bp, - strand  Genetic Position: Chr18, 35.1 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:55552
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin selection cassette was inserted into the sequence encoding the fourth transmembrane segment. This mutation is predicted to eliminate expression of a functional receptor. Ligand binding experiments confirmed that no functional receptor was expressed in the lung of homozygous mice. (J:55552)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Adrb2 Mutation:  17 strains or lines available
References
Original:  J:55552 Chruscinski AJ, et al., Targeted disruption of the beta2 adrenergic receptor gene. J Biol Chem. 1999 Jun 11;274(24):16694-700
All:  99 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/31/2018
MGI 6.12
The Jackson Laboratory