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Fgf10tm1Ska
Targeted Allele Detail
Summary
Symbol: Fgf10tm1Ska
Name: fibroblast growth factor 10; targeted mutation 1, Shigeaki Kato
MGI ID: MGI:1859647
Synonyms: fgf10-
Gene: Fgf10  Location: Chr13:118851199-118928651 bp, + strand  Genetic Position: Chr13, 67.14 cM, cytoband A3-A4
Alliance: Fgf10tm1Ska page
Submandibular gland abnormalities in Fgf10tm1Ska/Fgf10tm1Ska and Fgfr2tm1.1Dsn/Fgfr2tm1.1Dsn mice at E12.5

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:51966
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced 1.1 kb of sequence that contains the exon encoding the ATG translation initiation site and the amino terminal 110 amino acids of the encoded protein. (J:51966)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 144 assay results
2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 55 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fgf10 Mutation:  33 strains or lines available
References
Original:  J:51966 Sekine K, et al., Fgf10 is essential for limb and lung formation. Nat Genet. 1999 Jan;21(1):138-41
All:  56 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory