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Uncxtm1Akis
Targeted Allele Detail
Nomenclature
Symbol: Uncxtm1Akis
Name: UNC homeobox; targeted mutation 1, Andreas Kispert
MGI ID: MGI:1859373
Synonyms: Uncx4.1del
Gene: Uncx  Location: Chr5:139543494-139548179 bp, + strand  Genetic Position: Chr5, 78.75 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:62022
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsA deletion of the entire transcription unit of the Uncx4.1 gene was generated by introducing a loxP site 2-kb upstream of the transcription start site and a loxP-flanked neomycin cassette 5-kb to the second exon. Following homologous recombination in ES cells, cre recombinase was transiently expressed in order to excise loxP flanked sequences. ES cell lines carrying the deleted allele were used to generate founder mice. (J:62022)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 22 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Uncx Mutation:  10 strains or lines available
References
Original:  J:62022 Leitges M, et al., The paired homeobox gene Uncx4.1 specifies pedicles, transverse processes and proximal ribs of the vertebral column. Development. 2000 Jun;127(11):2259-67
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory