About   Help   FAQ
Nek1kat-2J
Spontaneous Allele Detail
Nomenclature
Symbol: Nek1kat-2J
Name: NIMA (never in mitosis gene a)-related expressed kinase 1; kidney, anemia and testis 2 Jackson
MGI ID: MGI:1858122
Synonyms: kat2J, kat2J
Gene: Nek1  Location: Chr8:60993195-61131346 bp, + strand  Genetic Position: Chr8, 30.91 cM
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Spontaneous
Mutation:    Insertion
    G insertion at position 966 causes frameshift and premature stop (J:59363)
Inheritance:    Recessive
Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Mice Carrying this Mutation: 6 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nek1 Mutation:  4 strains or lines available
Notes
Homozygous mutant mice have a latent onset, slowly progressing form of polycystic kidney disease (PKD) with renal pathology similar to the human autosomal-dominant PKD OMIM 173900, OMIM 600666). In addition, mutant mice show pleiotropic effects that include facial dysmorphism, dwarfing, male sterility, anemia, and cystic choroid plexus (J:59363).

References
Original:  J:37799 Janaswami PM, et al., Identification and genetic mapping of a new polycystic kidney disease on mouse chromosome 8. Genomics. 1997 Feb 15;40(1):101-7
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/23/2014
MGI 5.19
The Jackson Laboratory