Mlh1^tm1Rak
Targeted Allele Detail

Summary

• Symbol: Mlh1^tm1Rak
• Name: mutL homolog 1; targeted mutation 1, Raju Kucherlapati
• MGI ID: MGI:1858054
• Synonyms: mlh1-, Mlh1^-, Mlh1^delta
• Gene: Mlh1 Location: Chr9:111057296-111100854 bp, - strand Genetic Position: Chr9, 60.92 cM
• Alliance: Mlh1^tm1Rak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:33878
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Replacement of exon 2 and flanking intronic sequence with a neomycin cassette. (J:33878)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Mlh1^tm1Rak

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mlh1 Mutation: 42 strains or lines available

References

• Original: J:33878 Edelmann W, et al., Meiotic pachytene arrest in MLH1-deficient mice. Cell. 1996 Jun 28;85(7):1125-34
• All: 38 reference(s)