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Mlh1tm1Rak
Targeted Allele Detail
Nomenclature
Symbol: Mlh1tm1Rak
Name: mutL homolog 1 (E. coli); targeted mutation 1, Raju Kucherlapati
MGI ID: MGI:1858054
Synonyms: mlh1-, Mlh1-, Mlh1delta
Gene: Mlh1  Location: Chr9:111228228-111271608 bp, - strand  Genetic Position: Chr9, 60.92 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:33878
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    Replacement of exon 2 and flanking intronic sequence with a neomycin cassette. (J:33878)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mlh1 Mutation:  11 strains or lines available
References
Original:  J:33878 Edelmann W, et al., Meiotic pachytene arrest in MLH1-deficient mice. Cell. 1996 Jun 28;85(7):1125-34
All:  30 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory