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Nek1kat
Spontaneous Allele Detail
Nomenclature
Symbol: Nek1kat
Name: NIMA (never in mitosis gene a)-related expressed kinase 1; kidney, anemia and testis
MGI ID: MGI:1858030
Synonyms: kat
Gene: Nek1  Location: Chr8:60993195-61131346 bp, + strand  Genetic Position: Chr8, 30.91 cM
Mutation
origin
Strain of Origin:  RBF/Dn
Mutation
description
Allele Type:    Spontaneous
Mutation:    Intragenic deletion
    Nucleotides 791-2105 are deleted. (J:59363)
Inheritance:    Recessive
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nek1 Mutation:  4 strains or lines available
Notes
Homozygous mutant mice have a latent onset, slowly progressing form of polycystic kidney disease (PKD) with renal pathology similar to the human autosomal-dominant PKD OMIM 173900, OMIM 600666). In addition, mutant mice show pleiotropic effects that include facial dysmorphism, dwarfing, male sterility, anemia, and cystic choroid plexus (J:59363).

References
Original:  J:37799 Janaswami PM, et al., Identification and genetic mapping of a new polycystic kidney disease on mouse chromosome 8. Genomics. 1997 Feb 15;40(1):101-7
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory