Cryaa^tm1Wawr
Targeted Allele Detail

Summary

• Symbol: Cryaa^tm1Wawr
• Name: crystallin, alpha A; targeted mutation 1, Eric F Wawrousek
• MGI ID: MGI:1858025
• Synonyms: alphaA, alphaA^-, alphaAKO-127
• Gene: Cryaa Location: Chr17:31896905-31900704 bp, + strand Genetic Position: Chr17, 17.09 cM, cytoband A3-B
• Alliance: Cryaa^tm1Wawr page

Lens opacity in Cryaa^tm1Wawr/Cryaa^tm1Wawr mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:38210
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Insertion of a neomycin cassette preceeded by sequences containing translation termination codons in all three reading frames into the first exon. Northern blot analysis on homogenates of lenses from homozygous mutant mice indicated that no protein is produced from this allele. (J:38210)
• Inheritance: Recessive

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cryaa Mutation: 14 strains or lines available

References

• Original: J:38210 Brady JP, et al., Targeted disruption of the mouse alpha A-crystallin gene induces cataract and cytoplasmic inclusion bodies containing the small heat shock protein alpha B-crystallin. Proc Natl Acad Sci U S A. 1997 Feb 4;94(3):884-9
• All: 19 reference(s)