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Targeted Allele Detail
Symbol: Cryaatm1Wawr
Name: crystallin, alpha A; targeted mutation 1, Eric F Wawrousek
MGI ID: MGI:1858025
Synonyms: alphaA, alphaA-, alphaAKO-127
Gene: Cryaa  Location: Chr17:31677933-31681722 bp, + strand  Genetic Position: Chr17, 17.09 cM, cytoband A3-B
Lens opacity in Cryaatm1Wawr/Cryaatm1Wawr mice

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:38210
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsInsertion of a neomycin cassette preceeded by sequences containing translation termination codons in all three reading frames into the first exon. Northern blot analysis on homogenates of lenses from homozygous mutant mice indicated that no protein is produced from this allele. (J:38210)
Inheritance:    Recessive
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cryaa Mutation:  5 strains or lines available
Original:  J:38210 Brady JP, et al., Targeted disruption of the mouse alpha A-crystallin gene induces cataract and cytoplasmic inclusion bodies containing the small heat shock protein alpha B-crystallin. Proc Natl Acad Sci U S A. 1997 Feb 4;94(3):884-9
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.0
The Jackson Laboratory