Cryaatm1Wawr
Targeted Allele Detail
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Symbol: |
Cryaatm1Wawr |
Name: |
crystallin, alpha A; targeted mutation 1, Eric F Wawrousek |
MGI ID: |
MGI:1858025 |
Synonyms: |
alphaA, alphaA-, alphaAKO-127 |
Gene: |
Cryaa Location: Chr17:31896905-31900704 bp, + strand Genetic Position: Chr17, 17.09 cM, cytoband A3-B
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Alliance: |
Cryaatm1Wawr page
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Lens opacity in Cryaatm1Wawr/Cryaatm1Wawr mice
Show the 2 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:38210
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Parent Cell Line: |
J1 (ES Cell)
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Strain of Origin: |
129S4/SvJae
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Allele Type: |
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Targeted (Null/knockout) |
Mutation: |
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Insertion
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Mutation details: Insertion of a neomycin cassette preceeded by sequences containing translation termination codons in all three reading frames into the first exon. Northern blot analysis on homogenates of lenses from homozygous mutant mice indicated that no protein is produced from this allele.
(J:38210)
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Inheritance: |
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Recessive |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Cryaa Mutation: |
14 strains or lines available
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Original: |
J:38210 Brady JP, et al., Targeted disruption of the mouse alpha A-crystallin gene induces cataract and cytoplasmic inclusion bodies containing the small heat shock protein alpha B-crystallin. Proc Natl Acad Sci U S A. 1997 Feb 4;94(3):884-9 |
All: |
19 reference(s) |
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