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Cryaalop18
Spontaneous Allele Detail
Nomenclature
Symbol: Cryaalop18
Name: crystallin, alpha A; lens opacity 18
MGI ID: MGI:1858023
Synonyms: alphaA-His
Gene: Cryaa  Location: Chr17:31896905-31900704 bp, + strand  Genetic Position: Chr17, 17.09 cM, cytoband A3-B
Mutation
origin
Strain of Origin:  CBA/CaGnLeJ
Mutation
description
Allele Type:    Spontaneous
Mutation:    Single point mutation
 
Mutation detailsA G-to-A transition at coding nucleotide 161 of the mRNA that converts codon 54 from an arginine to a histidine (p.R54H). (J:59482)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cryaa Mutation:  12 strains or lines available
References
Original:  J:34933 Chang B, et al., Chromosomal localization of a new mouse lens opacity gene (lop18). (Correction: vol. 39(2):237). Genomics. 1996 Aug 15;36(1):171-3
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory