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Targeted Allele Detail
Symbol: Mettm1Cpo
Name: met proto-oncogene; targeted mutation 1, Carola Ponzetto
MGI ID: MGI:1858019
Synonyms: Met-, metd, MetD
Gene: Met  Location: Chr6:17463800-17573980 bp, + strand  Genetic Position: Chr6, 7.83 cM, cytoband A2
Germline Transmission:  Earliest citation of germline transmission: J:36244
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Mutation detailsA mutant human cDNA coding for the transmembrane and cytoplasmic domain of the receptor was inserted in-frame into mouse genomic sequences. The cDNA was followed by a neomycin resistance cassette. A fusion protein consisting of the murine extracellular domain fused to the human transmembrane and cytoplasmic domain carrying the mutations Y1349F and Y1356Fis produced from this allele. (J:36244)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 25 assay results
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Met Mutation:  4 strains or lines available
Original:  J:36244 Maina F, et al., Uncoupling of Grb2 from the Met receptor in vivo reveals complex roles in muscle development. Cell. 1996 Nov 1;87(3):531-42
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory