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Msh6tm1Rak
Targeted Allele Detail
Nomenclature
Symbol: Msh6tm1Rak
Name: mutS homolog 6 (E. coli); targeted mutation 1, Raju Kucherlapati
MGI ID: MGI:1858014
Synonyms: Msh6-
Gene: Msh6  Location: Chr17:87975050-87990883 bp, + strand  Genetic Position: Chr17, 57.87 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:44428
Parent Cell Line:  WW6 (ES Cell)
Strain of Origin:  STOCK 129/Sv and C57BL/6J and SJL
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin resistance gene was inserted at codon 336 within exon 4 of the gene, resulting in a stop codon 21 nucleotides downstream. No transcript for the targeted gene was detected on Northern blots of RNA extracted from two double-targeted ES cell lines. No protein product for the targeted gene was detected on Western blots of protein extracted from two double-targeted ES cell lines. (J:44428)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Msh6 Mutation:  10 strains or lines available
References
Original:  J:44428 Edelmann W, et al., Mutation in the mismatch repair gene Msh6 causes cancer susceptibility. Cell. 1997 Nov 14;91(4):467-77
All:  22 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory