About   Help   FAQ
Targeted Allele Detail
Symbol: Msh6tm1Rak
Name: mutS homolog 6; targeted mutation 1, Raju Kucherlapati
MGI ID: MGI:1858014
Synonyms: Msh6-
Gene: Msh6  Location: Chr17:87975050-87990883 bp, + strand  Genetic Position: Chr17, 57.87 cM
Germline Transmission:  Earliest citation of germline transmission: J:44428
Parent Cell Line:  WW6 (ES Cell)
Strain of Origin:  STOCK 129/Sv and C57BL/6J and SJL
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neomycin resistance gene was inserted at codon 336 within exon 4 of the gene, resulting in a stop codon 21 nucleotides downstream. No transcript for the targeted gene was detected on Northern blots of RNA extracted from two double-targeted ES cell lines. No protein product for the targeted gene was detected on Western blots of protein extracted from two double-targeted ES cell lines. (J:44428)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Msh6 Mutation:  41 strains or lines available
Original:  J:44428 Edelmann W, et al., Mutation in the mismatch repair gene Msh6 causes cancer susceptibility. Cell. 1997 Nov 14;91(4):467-77
All:  24 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.12
The Jackson Laboratory