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Targeted Allele Detail
Symbol: Ctnnb1tm1Mmt
Name: catenin (cadherin associated protein), beta 1; targeted mutation 1, Makoto M Taketo
MGI ID: MGI:1858008
Synonyms: B-cateninfl3, BcatGOF, beta-catact, beta-catc.a., beta-catenindeltaex3, beta-cateninlox-ex3, beta-cateninloxEx3, beta-catenin/loxP(ex3), beta-catex3, beta-catgof, beta-catloxEx3, Catnb(ex3)fl, Catnb(Flox3, Catnblox(ex3), Catnbtm1Tak, Ctnnb1ex3, Ctnnb1(Ex3)fl, Ctnnb1f(Ex3), Ctnnb1flx(ex3), Ctnnb1iGOF, Ctnnb1lox(ex3), Ctnnbllox(ex3), Ctnnblox(ex3), GOF
Gene: Ctnnb1  Location: Chr9:120933400-120960507 bp, + strand  Genetic Position: Chr9, 72.19 cM
Kidney agenesis in Ctnnb1tm1Mmt/Ctnnb1+ Tg(Hoxb7-cre)13Amc/0 mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:58367
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsInsertion of a PGK-neomycin resistance cassette introduced two loxP sites flanking exon 3 and the inserted cassette. Exon 3 contains phosphorylation target serine/threonine residues. Future deletion of exon 3 with cre recombinase would result in mRNA whose exons 2 and 4 are connected in frame. (J:58367)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 72 assay results
In Structures Affected by this Mutation: 47 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ctnnb1 Mutation:  22 strains or lines available
Original:  J:58367 Harada N, et al., Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene. EMBO J. 1999 Nov 1;18(21):5931-42
All:  405 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory