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Pou3f4tm1Tno
Targeted Allele Detail
Summary
Symbol: Pou3f4tm1Tno
Name: POU domain, class 3, transcription factor 4; targeted mutation 1, T Noda
MGI ID: MGI:1857991
Synonyms: Brn-4-
Gene: Pou3f4  Location: ChrX:109857886-109860813 bp, + strand  Genetic Position: ChrX, 48.2 cM
Alliance: Pou3f4tm1Tno page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:57298
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA PGK-neomycin resistance cassette replaced the coding region of this gene. Protein from homozygous mutant animals lacked DNA binding activity as determined by gel mobility shift assays. (J:57298)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pou3f4 Mutation:  3 strains or lines available
References
Original:  J:57298 Minowa O, et al., Altered cochlear fibrocytes in a mouse model of DFN3 nonsyndromic deafness [see comments]. Science. 1999 Aug 27;285(5432):1408-11
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory